Geometric and dosimetric accuracy of deformable image registration between average-intensity images for 4DCT-based adaptive radiotherapy for non-small cell lung cancer.

Yulun He Guillaume Cazoulat Carol Chia Chia Wu Christine B Peterson Molly McCulloch Brian M Anderson Julianne Pollard-LarkinPeter BalterZhongxing Liao Radhe Mohan Kristy K Brock

Published in: Journal of applied clinical medical physics (2021)

When the region of interest experiences <10 mm respiratory-induced motion, AVG-AVG DIR may provide sufficient geometric accuracy; conversely, extra attention is warranted, and phase-phase DIR is recommended. Dosimetrically, the differences in geometric accuracy between AVG-AVG and phase-phase DIRs did not impact global lung-based metrics. However, as more localized dose metrics are needed for toxicity assessment, phase-phase DIR may be required as its lower mean TRE improved voxel-based dosimetry.

Keyphrases

radiation therapy
deep learning
oxidative stress
mental health
convolutional neural network
high speed
locally advanced