Autophagy, Oxidative Stress and Cancer Development.
Elisabeth TaucherIurii MykoliukMelanie FediukFreyja-Maria Smolle-JuettnerPublished in: Cancers (2022)
Autophagy is an important cellular repair mechanism, aiming at sequestering misfolded and dysfunctional proteins and damaged cell organelles. Dysfunctions in the autophagy process have been linked to several diseases, like infectious and neurodegenerative diseases, type II diabetes mellitus and cancer. Living organisms are constantly subjected to some degree of oxidative stress, mainly induced by reactive oxygen and nitrogen species. It has been shown that autophagy is readily induced by reactive oxygen species (ROS) upon nutrient deprivation. In recent years, research has increasingly focused on outlining novel therapeutic targets related to the autophagy process. With this review of the literature, we want to give an overview about the link between autophagy, oxidative stress and carcinogenesis.
Keyphrases
- oxidative stress
- cell death
- endoplasmic reticulum stress
- signaling pathway
- dna damage
- induced apoptosis
- reactive oxygen species
- diabetic rats
- ischemia reperfusion injury
- papillary thyroid
- type diabetes
- stem cells
- squamous cell
- squamous cell carcinoma
- single cell
- cell therapy
- adipose tissue
- amino acid
- insulin resistance
- gram negative
- heat stress