Citrullination of HP1γ chromodomain affects association with chromatin.

Meike WieseAndrew J BannisterSrinjan BasuWayne BoucherKai WohlfahrtMaria A ChristophorouMichael L NielsenDavid KlenermanErnest D LaueTony Kouzarides

Published in: Epigenetics & chromatin (2019)

Citrullination is a novel post-translational modification of the structural heterochromatin protein HP1γ in mESCs that is dynamically regulated during mESC differentiation. The citrullinated residues lie within the HP1γ chromodomain and are important for H3K9me3 binding in vitro and chromatin association in vivo.

Keyphrases

transcription factor
gene expression
dna damage
binding protein
dna binding
oxidative stress
amino acid