Cartilage Topography Assessment with Local Area Cartilage Segmentation (LACS) for Knee MRI.

LACS cartilage thickness measurement in the medial and lateral femur and tibia correlated well with established manual segmentation-based measurement, with similar responsiveness to change, among knees with symptomatic knee OA. LACS measurement of cartilage plate topography enables spatio-temporal analysis of cartilage loss in future knee OA studies.