Exploring the Thermal-Oxidative Stability of Azithromycin Using a Thermoactivated Sensor Based on Cerium Molybdate and Multi-Walled Carbon Nanotubes.
Heryka R A CostaAndré O SantosYago N TeixeiraMaria A S SilvaValker A FeitosaSimone MoraisThiago M B F OliveiraPublished in: Nanomaterials (Basel, Switzerland) (2024)
The chemical stability of azithromycin (AZM) may be compromised depending on the imposed thermo-oxidative conditions. This report addresses evidence of this process under varying conditions of temperature (20-80 °C), exposure time to UV radiation (1-3 h irradiation at 257 nm), and air saturation (1-3 h saturation with atmospheric air at 1.2 L min -1 and 15 kPa) through electrochemical measurements performed with a thermoactivated cerium molybdate (Ce 2 (MoO 4 ) 3 )/multi-walled carbon nanotubes (MWCNT)-based composite electrode. Thermal treatment at 120 °C led to coordinated water elimination in Ce 2 (MoO 4 ) 3 , improving its electrocatalytic effect on antibiotic oxidation, while MWCNT were essential to reduce the charge-transfer resistance and promote signal amplification. Theoretical-experimental data revealed remarkable reactivity for the irreversible oxidation of AZM on the working sensor using phosphate buffer (pH = 8) prepared in CH 3 OH/H 2 O (10:90%, v / v ). Highly sensitive (230 nM detection limit) and precise (RSD < 4.0%) measurements were recorded under these conditions. The results also showed that AZM reduces its half-life as the temperature, exposure time to UV radiation, and air saturation increase. This fact reinforces the need for continuous quality control of AZM-based pharmaceuticals, using conditions closer to those observed during their transport and storage, reducing impacts on consumers' health.
Keyphrases
- walled carbon nanotubes
- quality control
- label free
- healthcare
- public health
- hydrogen peroxide
- mental health
- big data
- gold nanoparticles
- artificial intelligence
- ionic liquid
- molecularly imprinted
- fluorescent probe
- human health
- sensitive detection
- real time pcr
- high resolution
- quantum dots
- climate change
- liquid chromatography
- replacement therapy
- loop mediated isothermal amplification
- visible light