Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China.

En-Lin DongChong WangShuang WuYing-Qian LuXiao-Hong LinHui-Zhen SuMiao ZhaoJin HeLi-Xiang MaNing WangWan-Jin ChenXiang Lin

Published in: Molecular neurodegeneration (2018)

Our study present a comprehensive clinical spectrum and genetic landscape for HSP in China. We have also provided additional evidences for mitochondrial and autolysosomal-mediated pathways in the pathogenesis of HSP.

Keyphrases

heat shock protein
genome wide
oxidative stress
copy number
dna methylation
botulinum toxin