Crohn's disease and early exposure to thiopurines are independent risk factors for mosaic chromosomal alterations in patients with inflammatory bowel diseases.
Yoichi KakutaHideya IwakiJunji UmenoYosuke KawaiMasahiro KawaharaTetsuya TakagawaYusuke ShimoyamaTakeo NaitoRintaro MoroiMasatake KurohaHisashi ShigaKenji WatanabeShiro NakamuraHiroshi NakaseMakoto SasakiHiroyuki HanaiYuta FuyunoAtsushi HiranoTakayuki MatsumotoHisaaki KudoNaoko MinegishiMinoru NakamuraTadakazu HisamatsuAkira AndohMasao NagasakiKatsushi TokunagaYoshitaka Kinouchinull nullAtsushi MasamunePublished in: Journal of Crohn's & colitis (2021)
The difference in mCAs between patients with CD and UC supports the higher incidence of hematopoietic malignancies in CD. Caution should be exercised when using thiopurines in young patients with IBD, particularly CD, in light of possible chromosomal alterations.