Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes.

Sandra Rodríguez-RoderoEdelmiro Menéndez-TorreGustavo Fernández-BayónPaula Morales-SánchezLourdes SanzEstrella TurienzoJuan José GonzálezCeferino Martinez-FaedoLorena Suarez-GutiérrezJessica AresLucia Díaz-NayaAlicia Martin-NietoJuan L Fernández-MoreraMario F FragaElías Delgado-Álvarez

Published in: PloS one (2017)

The differential methylation profile of the HOOK2 gene in individuals with T2D and obesity might be related to the attendant T2D, but further studies are required to identify the potential role of HOOK2 gene in T2D disease. The finding of gender differences in T2D methylation of HOOK2 also warrants further investigation.

Keyphrases

genome wide
dna methylation
type diabetes
insulin resistance
adipose tissue
copy number
metabolic syndrome
weight loss
genome wide identification
gene expression
weight gain
high fat diet
high fat diet induced
cardiovascular disease
skeletal muscle
risk assessment
human health
genome wide analysis