Unhealthy white matter connectivity, cognition, and racialization in older adults.

Sarah K RoyseBeth E SnitzJames B HengeniusTheodore J HuppertRebecca E RoushRebecca E EhrenkranzJames D WilsonMarnie BertoletAlexandria C ReeseGeraldine CisnerosKatey PotopenkoJames T BeckerAnn D CohenC Elizabeth Shaaban

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Unhealthy white matter connectivity (UWMC) in Alzheimer's disease (AD) pathology-affected brain regions is associated with cognition. Relationships between UWMC and cognition are similar between Black American (BA) and non-Hispanic White (nHW) individuals. More UWMC may partially drive higher clinical AD burden in BA versus nHW populations. UWMC risk factors, particularly social and environmental, should be identified.

Keyphrases

white matter
risk factors
multiple sclerosis
healthcare
physical activity
african american
brain injury
blood brain barrier
cerebral ischemia