Exploring first-degree family history in a cohort of Portuguese Alzheimer's disease patients: population evidence for X-chromosome linked and recessive inheritance of risk factors.

Miguel Tábuas-PereiraCatarina BernardesJoão DurãesMarisa LimaAna Rita NogueiraJorge SaraivaTeresa TábuasMariana CoelhoKimberly PaquetteKaitlyn WestraCélia Kun-RodriguesMaria Rosário AlmeidaInês BaldeirasJosé BrásRita GuerreiroIsabel Santana

Published in: Journal of neurology (2024)

Our study gives evidence supporting an increased risk of developing AD associated with an X-linked inheritance pattern and remote consanguinity.

Keyphrases

risk factors
end stage renal disease
mitochondrial dna
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
copy number
intellectual disability
gene expression
cognitive decline
autism spectrum disorder
patient reported outcomes