Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer.
Simon LecoutreKarine ClémentIsabelle DugailPublished in: International journal of molecular sciences (2022)
Adipose tissue dysfunction is strongly associated with obesity and its metabolic complications such as type 2 diabetes and cardiovascular diseases. It is well established that lipid-overloaded adipose tissue produces a large range of secreted molecules that contribute a pro-inflammatory microenvironment which subsequently disseminates towards multi-organ metabolic homeostasis disruption. Besides physiopathological contribution of adipose-derived molecules, a new paradigm is emerging following the discovery that adipocytes have a propensity to extrude damaged mitochondria in the extracellular space, to be conveyed through the blood and taken up by cell acceptors, in a process called intercellular mitochondria transfer. This review summarizes the discovery of mitochondria transfer, its relation to cell quality control systems and recent data that demonstrate its relevant implication in the context of obesity-related adipose tissue dysfunction.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- high fat diet induced
- high fat diet
- cell death
- metabolic syndrome
- quality control
- weight loss
- reactive oxygen species
- endoplasmic reticulum
- cardiovascular disease
- single cell
- small molecule
- cell therapy
- glycemic control
- high throughput
- oxidative stress
- weight gain
- stem cells
- risk factors
- electronic health record
- electron transfer
- artificial intelligence