Secretion of heat shock -60, -70 kD protein, IL-1β and TNFα levels in serum of a term normal pregnancy and patients with pre-eclampsia development.
María C Álvarez-CabreraEdgar Barrientos-GaleanaAsyadette Barrera-GarcíaMauricio Osorio-CaballeroJesús F AcevedoOscar Flores-HerreraNéstor F DíazAnayansí Molina-HernándezGuadalupe García-LópezHéctor Flores-HerreraPublished in: Journal of cellular and molecular medicine (2018)
The extracellular heat shock proteins (eHsp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of eHsp-60, -70, IL-1β and TNFα in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia (PE). Our results indicate significant increase of these markers in patients with PE with respect to healthy pregnant patients without active labor. Finally, the concentration of eHsp-60 and -70 correlated positively with the hepatic dysfunction markers uric acid, lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) glutamic pyruvic transaminase (GPT), and inflammatory IL-1β and TNFα response. In conclusion, our results demonstrate a strong associated between Hsp and marker of hepatic dysfunction.
Keyphrases
- heat shock
- uric acid
- oxidative stress
- heat stress
- heat shock protein
- rheumatoid arthritis
- pregnant women
- end stage renal disease
- gestational age
- preterm infants
- pregnancy outcomes
- newly diagnosed
- ejection fraction
- metabolic syndrome
- peritoneal dialysis
- chronic kidney disease
- weight gain
- single molecule
- gene expression
- protein protein
- early onset
- prognostic factors
- preterm birth
- binding protein
- physical activity
- birth weight
- molecular dynamics simulations
- umbilical cord