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CD47-blocking Antibody ZL-1201 Promotes Tumor-associated Macrophage Phagocytic Activity and Enhances the Efficacy of the Therapeutic Antibodies and Chemotherapy.

Anthony CaoJiaqing YiXinyan TangChristopher W SzetoRenyi WuBing WanXu FangShou LiLei WangLina WangJing LiQiuping YeTom HuangKarl HsuOmar KabbarahHaiying Zhou
Published in: Cancer research communications (2022)
ZL-1201 is a novel anti-CD47 antibody that has improved hematologic safety profiles and combines with SoC, including mAbs and chemotherapies, to potently facilitate phagocytosis and antitumor efficacy.
Keyphrases
  • adipose tissue
  • nk cells
  • squamous cell carcinoma
  • locally advanced
  • chemotherapy induced