Electronic health record (EHR) based postmarketing surveillance of adverse events associated with pediatric off-label medication use: A case study of short-acting beta-2 agonists and arrhythmias.

Angela S CzajaMichelle E RossWeiwei LiuAlexander G FiksRussell LocalioRichard C WassermanRobert W GrundmeierWilliam G Adamsnull null

Published in: Pharmacoepidemiology and drug safety (2018)

Using EHR data, we could estimate the risk of a rare event associated with medication use and determine difference in risk related to on-label versus off-label status. These findings support the value of EHR-based data for postmarketing drug studies in the pediatric population.

Keyphrases

electronic health record
adverse drug
clinical decision support
public health
emergency department
drug administration
young adults
case control
artificial intelligence