In depth analysis of the HIV reservoir confirms effectiveness and safety of DTG/3TC in a phase 4 randomized controlled switch trial (RUMBA).

Marie-Angélique De ScheerderSophie DegrooteMareva Delporte Maja Kiselinova Wim TrypsteenLara VinckeEvelien De SmetBram Van Den Eeckhout Loïc SchrooyenMaxime VerschooreCamilla MucciniSophie VanherrewegeEls CaluweDe Buyser Stefanie Sarah Gerlo Evy E Blomme Linos Vandekerckhove

Published in: The Journal of infectious diseases (2024)

This study confirms the safety of DTG/3TC compared to B/F/TAF through viral control after in-depth investigations of the intact HIV-1 reservoir, HIV-1 transcription and inflammatory markers.

Keyphrases

antiretroviral therapy
hiv positive
hiv testing
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
phase iii
phase ii
clinical trial
optical coherence tomography
open label
south africa
sars cov
double blind
placebo controlled