Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment.
Anna DelpratoEmily XiaoDevika ManojPublished in: Behavioral and brain functions : BBF (2022)
Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses.
Keyphrases
- intellectual disability
- autism spectrum disorder
- genome wide
- systematic review
- healthcare
- cognitive impairment
- mental health
- bioinformatics analysis
- genome wide identification
- signaling pathway
- genome wide analysis
- dna methylation
- gene expression
- multiple sclerosis
- copy number
- health information
- electronic health record
- social media
- blood brain barrier
- artificial intelligence
- endoplasmic reticulum stress
- subarachnoid hemorrhage