Hdac8 Inhibitor Alleviates Transverse Aortic Constriction-Induced Heart Failure in Mice by Downregulating Ace1.
Tingwei ZhaoHae Jin KeeSeung-Jung KeeYoungkeun AhnPublished in: Oxidative medicine and cellular longevity (2022)
Treatment with PCI34051 enhanced cardiac and lung functions in the TAC-induced heart failure mouse model. These data suggest that HDAC8 is a potential novel therapeutic target for heart failure accompanied by pathological lung diseases.
Keyphrases
- heart failure
- left ventricular
- mouse model
- high glucose
- diabetic rats
- atrial fibrillation
- cardiac resynchronization therapy
- acute heart failure
- acute myocardial infarction
- coronary artery disease
- histone deacetylase
- percutaneous coronary intervention
- electronic health record
- angiotensin ii
- type diabetes
- oxidative stress
- adipose tissue
- endothelial cells
- skeletal muscle
- st segment elevation myocardial infarction
- antiplatelet therapy
- big data
- risk assessment
- spinal cord injury
- climate change
- combination therapy
- high fat diet induced
- artificial intelligence