Single-cell RNA sequencing identifies senescence as therapeutic target in rhabdomyolysis-induced acute kidney injury.
Snigdha N RaoMargot ZahmAudrey CasemayouMarie BuleonStanislas FaguerGuylène FeuilletJason S IacovoniOlivier P JoffreIgnacio Gonzalez-FuentesEmeline LhuillierFrédéric MartinsElodie RiantAlexia Zakaroff-GirardJoost P SchanstraJean Sébastien Saulnier BlacheJulie BellierePublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
scRNASeq unmasked novel transitional macrophage subpopulation associated with RM-AKI characterized by the activation of cellular senescence processes. This work provides a proof-of-concept that senolytics nephroprotective effects may rely, at least in part, on subtle immune modulation.