Effect of Lidocaine on Viability and Gene Expression of Human Adipose-derived Mesenchymal Stem Cells: An in vitro Study.
Hai NieEva KubrovaTao WuJanet M DenbeighChristine HuntAllan B DietzJay SmithWenchun QuAndre J van WijnenPublished in: PM & R : the journal of injury, function, and rehabilitation (2019)
Lidocaine is toxic to MSCs in a dose- and time- dependent manner. MSC exposure to high (4-8 mg/mL) concentrations of lidocaine for prolonged periods can affect their biologic functions. Although the exposure time in vivo is short, it is essential to choose safe concentrations when applying lidocaine along with MSCs to avoid compromising the viability and potency of the stem cell therapy.