Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis.
Yuri Matteo FalzoneTeuta DomiAlessandra MandelliLaura PozziParide SchitoTommaso RussoAlessandra BarbieriRaffaella FazioMaria Antonietta VolontèGiuseppe MagnaniUbaldo Del CarroPaola CarreraAndrea MalaspinaFederica AgostaAngelo QuattriniRoberto FurlanMassimo FilippiNilo RivaPublished in: European journal of neurology (2022)
NfL is a useful biomarker for the diagnosis of ALS and the strongest predictor of survival. UCHL1 is an independent prognostic factor helpful in stratifying survival in patients with low NfL levels, likely to have slowly progressive disease. GFAP reflects extramotor involvement, namely cognitive impairment or frontotemporal dementia.