Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-κB pathway.
Rui-Xiang ChenWang-Jie JiangShuo-Chen LiuZi-Yi WangZhi-Bo WangTao ZhouYan-An-Lan ChenJi-Fei WangJiang ChangYi-Rui WangYao-Dong ZhangXue-Hao WangXiang-Cheng LiChang Xian LiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Our study has identified the protective role of ApoA-1 in hepatic I/R injury through inhibiting pyroptosis in macrophages via TLR4-NF-κB pathway. The effect of ApoA-1 may provide a novel therapeutic approach for hepatic I/R injury.