Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer.

Xiaoya ZhaoJianfei FuWanfen TangLiangliang YuWenxia Xu

Published in: OncoTargets and therapy (2020)

Inhibition of serine metabolism reduced H3K4 tri-methylation and increased the density of chromatin, which leads to decreased toxicity and pro-apoptotic effect of platinum chemotherapeutic drugs on gastric cancer cells.

Keyphrases

genome wide
anti inflammatory
cell death
protein kinase
gene expression
dna methylation
dna damage
transcription factor
oxidative stress