Platelets regulate leucocyte responses to Toll-like receptor stimulation.

This study challenges the notion that platelets act solely in a pro-inflammatory manner. Rather, platelets are complex immunomodulators that regulate leucocyte responses to TLR stimulation in a TLR agonist-specific manner. Platelets may modulate leucocyte responses to dampen inflammation, and this platelet effect may play an important role in reducing inflammation-mediated host damage.