Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti-PD-(L)1 Therapies in Non-Small Cell Lung Cancer.

Wenfeng FangYuxiang MaJiani C YinShaodong HongHua-Qiang ZhouAo WangFufeng WangHua BaoXue WuYunpeng YangYan HuangHongyun ZhaoYang W ShaoLi Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We identified novel genomic biomarkers that were predictive of response to anti-PD-(L)1 therapies. Our findings suggest that comprehensive profiling of TMB and the aforementioned molecular markers could result in greater predictive power of response to ICI therapies in NSCLC.

Keyphrases

copy number
genome wide
small cell lung cancer
single cell
gene expression