Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay.

Hamiyet Donmez-Altuntas Serap Sahin Ergul Pinar Altin-Celik Kadir Bulut Hamiyet Eci Roglu Ramazan Uzen Gulsah Gunes Sahin Nurhayat Tuğra Özer Sahın Temel Turkmen Bahadir Arikan Aliye Esmaoglu Recep Civan Yüksel Murat Sungur Kursat Gundogan

Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2023)

The results of the present study showed that occludin, claudin-1, tricellulin and zonulin proteins, as well as I-FABP, D-lactate and citrulline, may be used as promising biomarkers for the evaluation of disease severity in critically ill trauma patients, despite the complexity of the analysis of various barrier markers. However, our results should be supported by future studies.

Keyphrases

current status
trauma patients
intensive care unit
binding protein
mechanical ventilation
acute respiratory distress syndrome