Apoptosis of mural granulosa cells is increased in women with diminished ovarian reserve.

Yuting FanYajie ChangLina WeiJianhui ChenJingjie LiSierra GoldsmithSherman J SilberXiaoyan Liang

Published in: Journal of assisted reproduction and genetics (2019)

A significantly higher apoptosis rate of mural granulosa cells was correlated with worse ovarian response, with fewer egg and embryo numbers in IVF/ICSI, as well as with age. Early apoptosis rate of cumulus cellsmight also have influence on clinical pregnancy.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
pi k akt
oxidative stress
pregnancy outcomes
signaling pathway
type diabetes
preterm birth
insulin resistance