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Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs.

Maheswary MuniandyVidya VelagapudiAntti HakkarainenJesper LundbomNina LundbomAila RissanenJaakko A KaprioKirsi H PietiläinenMiina Ollikainen
Published in: International journal of obesity (2005) (2018)
Different fat depots share metabolites associating with general adiposity. BMI and HDL-C associated with the most pronounced and specific metabolomic signature. Metabolomics profiling can be used to identify distinct subgroups of individuals that differ by cholesterol measures. Most of the observed metabolite-phenotype associations are free of confounding by genetics and environmental factors shared by the co-twins.
Keyphrases
  • risk factors
  • ms ms
  • single cell
  • weight gain
  • adipose tissue
  • mass spectrometry
  • body mass index
  • insulin resistance
  • genome wide
  • low density lipoprotein
  • metabolic syndrome
  • physical activity