Using explainable artificial intelligence to identify linguistic biomarkers of amyloid pathology in primary progressive aphasia.

Our work improves previous research which indicates connected speech is a useful diagnostic input for prediction of the presence of amyloid-β in patients with PPA. Further, we leverage XAI techniques to reveal novel linguistic features that can be tested in clinical practice in the appropriate subspecialty setting. Computational linguistic analysis of connected speech shows great promise as a novel assessment method in patients with AD and related disorders.