Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study.

Mario CacceseTamara Ius Matteo Simonelli Angelo Paolo Dei Tos Daniela CesselliAngelo DipasqualeFrancesco CavallinMarta PadovanAlessandro SalvalaggioMarina Paola GardimanMiran SkrapVittorina ZagonelGiuseppe Lombardi

Published in: International journal of molecular sciences (2020)

MMR protein expression status did not affect survival in HGG patients. We identified clinical and molecular characteristics correlating with immunohistochemical loss of MMR proteins expression. A large study should be performed to analyze its predictive role of immune checkpoint inhibitor efficacy in these subgroups of patients.

Keyphrases

high grade
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported