Long-Term Exposure to Morphine Induces Cross-Tolerance to Acute Antinociceptive Effect of Remifentanil on Somatic and Visceral Stimuli in Rats.

Hideaki MoriTatsuya HashimotoTetsuro NikaiMotohide FuruyaMai HattoriYukiko KatsubeYoji Saito

Published in: Journal of pain research (2022)

Our results indicate that morphine-tolerant rats exhibit cross-tolerance to remifentanil's acute antinociceptive effects on somatic and visceral stimuli. Cross-tolerance to remifentanil should be considered in the perioperative management of patients using morphine.

Keyphrases

liver failure
respiratory failure
insulin resistance
drug induced
aortic dissection
copy number
anti inflammatory
patients undergoing
cardiac surgery
hepatitis b virus
type diabetes
gene expression
metabolic syndrome
skeletal muscle
acute kidney injury
acute respiratory distress syndrome