Near-IR absorbing J-aggregates of a phenanthrene-fused BODIPY as a highly efficient photothermal nanoagent.
Xing GuoMao LiHao WuWanle ShengYuanmei FengChangjiang YuLijuan JiaoErhong HaoPublished in: Chemical communications (Cambridge, England) (2020)
A phenanthrene-[b]-fused BODIPY exhibited well-defined J-aggregation behavior in both pure hydrocarbon solution and aqueous solution. The highly stable J-aggregates showed narrowed and largely red-shifted absorption with λmax of 840 nm and enhanced molar absorption coefficients (271 000 M-1 cm-1). Encapsulation of J-aggregates within a micellar nanocapsule resulted in nanoparticles that demonstrated good biocompatibility, excellent photothermal stability, high photothermal conversion ability (η ∼ 46.9%) and an effective phototoxicity (IC50 ∼ 2 μg mL-1 in HeLa cells) under 808 nm laser irradiation.
Keyphrases
- photodynamic therapy
- highly efficient
- aqueous solution
- cancer therapy
- cell cycle arrest
- drug release
- induced apoptosis
- drug delivery
- living cells
- fluorescent probe
- cell death
- oxidative stress
- radiation therapy
- radiation induced
- endoplasmic reticulum stress
- cell proliferation
- signaling pathway
- high resolution
- mass spectrometry
- walled carbon nanotubes