Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1.
Rui-Xi ZhouYu-Yao LiYi QuQun HuangXue-Mei SunDe-Zhi MuXi-Hong LiPublished in: CNS neuroscience & therapeutics (2019)
During SAE, IRGM1 can at least partially regulate apoptosis and autophagy in hippocampal neurons through the p38 MAPK signaling pathway.
Keyphrases
- endoplasmic reticulum stress
- signaling pathway
- cell death
- oxidative stress
- induced apoptosis
- cell cycle arrest
- pi k akt
- cerebral ischemia
- acute kidney injury
- intensive care unit
- early onset
- epithelial mesenchymal transition
- spinal cord
- high fat diet induced
- temporal lobe epilepsy
- subarachnoid hemorrhage
- type diabetes
- spinal cord injury
- cell proliferation
- skeletal muscle