Women with polycystic ovary syndrome (PCOS) have a substantially increased risk for diabetes and cardiovascular disease. Obstructive sleep apnea (OSA) is the most common sleep disorder in PCOS. Recent population-based studies indicate a high incidence of OSA among adult women with PCOS. Obesity and increasing age are the main factors for this association. There is strong evidence indicating that OSA is an important modulator of metabolic risk in the general population. There is also some evidence to suggest that OSA may contribute to insulin resistance and glucose intolerance among women PCOS, and thus increase their metabolic risk. The potential mechanisms for adverse metabolic consequences of OSA are likely to be multiple. Whether treatment of OSA in PCOS improves metabolic outcomes requires further rigorous research.
Keyphrases
- polycystic ovary syndrome
- obstructive sleep apnea
- insulin resistance
- positive airway pressure
- cardiovascular disease
- type diabetes
- adipose tissue
- metabolic syndrome
- sleep apnea
- skeletal muscle
- high fat diet induced
- physical activity
- emergency department
- blood pressure
- glycemic control
- coronary artery disease
- young adults
- blood glucose
- sleep quality
- breast cancer risk
- cardiovascular events
- replacement therapy
- pregnant women