Loss of NAT10 alleviates maternal high-fat diet-induced hepatic steatosis in male offspring of mice.

Qian-Ren ZhangJian-Bin ZhangFeng ShenRui XueRui-Xu YangTian-Yi RenJian-Gao Fan

Published in: Obesity (Silver Spring, Md.) (2024)

NAT10 deletion in offspring hepatocytes ameliorates maternal HFD-induced hepatic steatosis through decreasing mRNA stability of CD36 and FATP2, highlighting NAT10 as a potential therapeutic target for pediatric MASLD.

Keyphrases

high fat diet induced
high fat diet
insulin resistance
birth weight
adipose tissue
pregnancy outcomes
metabolic syndrome
skeletal muscle
mouse model
type diabetes
drug induced
diabetic rats
liver injury
gestational age
human health
binding protein
physical activity
body mass index
wild type