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The effects of common structural variants on 3D chromatin structure.

Omar ShantaAmina Noornull nullJonathan Sebat
Published in: BMC genomics (2020)
Our study demonstrates that common SVs in the population impact long-range chromatin structure, and deletions and inversions have distinct signatures. However, the effects that we observe are subtle and variable between loci. Genome-wide analysis of chromatin conformation in large cohorts will be needed to quantify the influence of common SVs on chromatin structure.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • dna damage
  • gene expression
  • transcription factor
  • oxidative stress