Latest Advances in the Application of Humanized Mice Model for Staphylococcus aureus.

Staphylococcus aureus (SA) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis and septicemia. The mice models have greatly facilitated the development of SA studies. However, due to the substantial differences in immune system between mice and humans, the conventional mice studies are not predictive of success in humans, in which case humanized mice (HM) may overcome this limitation to some extent. HM can be used to study the human-specific virulence factors produced by SA and the mechanisms by which SA interacts with humans. This review outlined the latest advances in HM models used in SA studies.