Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer.

Pan Juncheng Adrien JosephAntoine LafargeIsabelle MartinsFlorine ObristJonathan G PolEster SaavedraSijing LiAllan SauvatGiulia CerratoSarah LévesqueMarion LeducOliver KeppSylvère DurandFanny AprahamianNitharsshini NirmalathansanJudith MichelsGuido KroemerMaria Castedo

Published in: Journal for immunotherapy of cancer (2022)

These results prove at the genetic level that PARP1 activity within malignant cells modulates the tumor microenvironment.

Keyphrases

dna damage
dna repair
induced apoptosis
cell cycle arrest
genome wide
cell death
signaling pathway
dna methylation
cell proliferation