Synthesis, insecticidal activity, and ensembled docking of nitroguanidines bearing S- and R-proline.

Alfredo Rodríguez-HernándezIsrael Bonilla-LandaAbraham Marcelino Vidal LimónArturo Ibarra-JuárezFelipe Barrera-MéndezFrancisco Javier Enríquez MedranoRamón E Díaz de LeónJosé Luis Olivares-Romero

Published in: Pest management science (2023)

The results suggest that compound R6 is an excellent lead enantiopure insecticide for future development in the field of crop protection. Furthermore, intermolecular interactions between nicotinic acetylcholine receptors and the R enantiomer displays a lower score which mean a higher affinity to the nAChR receptor and the π-π interactions are more stable than the S derivative. © 2023 Society of Chemical Industry.

Keyphrases

molecular dynamics
climate change
molecular dynamics simulations
current status
protein protein
aedes aegypti
small molecule
zika virus
water soluble
quantum dots