Metformin Abrogates Age-Associated Ovarian Fibrosis.

Curtis William McCloskey David P CookBrendan S KellyFeryel AzziChristian H AllenAmanda ForsythJeremy UphamKatey J RaynerDouglas A GrayRobert W BoydSangeeta MurugkarBryan LoDominique TrudelMary K SentermanBarbara C Vanderhyden

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data support a novel hypothesis that unifies the primary nonhereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a premetastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis.See related commentary by Madariaga et al., p. 523.

Keyphrases

risk factors
electronic health record
liver fibrosis
big data
human health
risk assessment
data analysis
climate change