Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response.

Kazi Mokim AhmedRatna VeeramachaneniDefeng DengNagireddy PutluriVasanta PutluriMaria F CardenasDavid A WheelerWilliam K DeckerAndy I FrederickSawad KaziAndrew G SikoraVlad C Sandulache Mitchell J Frederick

Published in: Journal for immunotherapy of cancer (2022)

GPX2 overexpression represents a novel potentially targetable effector of immune escape in cold tumors.

Keyphrases

stem cells
cell proliferation
dendritic cells
hydrogen peroxide
regulatory t cells
transcription factor
type iii