Markers of gastrointestinal permeability and dysbiosis in premenopausal women with PCOS: a case-control study.

Shilpa LingaiahRiikka K ArffmanLaure Morin-PapunenJuha S TapanainenTerhi Piltonen

Published in: BMJ open (2021)

Intestinal permeability markers zonulin and FABP2, and the dysbiosis marker indican do not seem to be altered in women with PCOS at age 46 compared with BMI-matched controls. Serum zonulin levels correlated with BMI, insulin resistance and inflammatory marker levels, but did not segregate women with PCOS and controls. This suggests that metabolic factors, but not PCOS per se, is the driving force of dysbiosis in premenopausal women with PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
body mass index
adipose tissue
postmenopausal women
metabolic syndrome
endothelial cells
high fat diet
oxidative stress
single molecule
physical activity
binding protein
weight loss