The potential association between metabolic syndrome and risk of post-surgical adhesion.
Gordon A FernsMohammad-Hassan ArjmandMohammad-Hassan ArjmandPublished in: Archives of physiology and biochemistry (2020)
Metabolic syndrome (MetS) is defined by the clustering of several associated with a group of disorders that include: obesity, dyslipidemia, hypertension, and insulin resistance. The incidence of MetS is increasing globally around the world. Indeed the rates of different types of surgery in older or younger patients with Mets are increasing and they are exposed to a wide range of operations including abdominal, pelvic, urologic, or any invasive procedures. Post-surgical adhesion is a common problem and is a challenge for the surgeon. Despite many studies on its pathogenesis, there remain many un-answered questions about it, for example why certain tissues and patients are more at higher risk of post-surgical adhesions. Many studies have suggested that MetS is associated with up-regulating molecular mechanisms leading to chronic inflammation and hypercoagulability. In this review, we discuss some of the molecular mechanisms by MetS may enhance post-surgical adhesion, and particularly regarding those involved in coagulation and inflammation.
Keyphrases
- metabolic syndrome
- insulin resistance
- oxidative stress
- type diabetes
- adipose tissue
- uric acid
- ejection fraction
- skeletal muscle
- biofilm formation
- high fat diet induced
- minimally invasive
- risk factors
- physical activity
- newly diagnosed
- cardiovascular disease
- high fat diet
- gene expression
- coronary artery bypass
- coronary artery disease
- cystic fibrosis
- cardiovascular risk factors
- staphylococcus aureus
- percutaneous coronary intervention
- robot assisted
- surgical site infection