Interactions between in vivo neuronal-glial markers, side of hippocampal sclerosis, and pharmacoresponse in temporal lobe epilepsy.
Luciana Ramalho Pimentel-SilvaRaphael F CassebMônica M CordeiroBruno A G CamposMarina K M AlvimFábio RogerioClarissa L YasudaFernando CendesPublished in: Epilepsia (2020)
Our study revealed a spectrum of neuronal-glial changes in TLE, which was associated with pharmacoresistance, being more severe in left-sided HS and less severe in MRI-negative TLE. These noninvasive, in vivo biomarkers provide valuable additional information about the interhemispheric differences in metabolic dysfunction, seizure burden, and HS, and may help to predict pharmacoresistance.