Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.
Frank QianMatti A RookusGoska LeslieHarvey A RischMark H GreeneCora M AalfsMuriel A AdankJulian AdlardBjarni A AgnarssonMunaza AhmedKristiina AittomäkiIrene L AndrulisNorbert ArnoldBanu K ArunMargreet G E M AusemsJacopo AzzolliniDaniel BarrowdaleJulian BarwellJavier BenitezKatarzyna BiałkowskaValérie BonadonaJulika BordeAke BorgAngela R BradburyJoan BrunetSaundra S BuysTrinidad CaldésMaria A CaligoIan CampbellJonathan CarterJocelyne ChiquetteWendy K ChungKathleen B M ClaesJ Margriet ColléeMarie-Agnès Collonge-RameFergus J CouchMary B DalyCapucine DelnatteOrland DiezSusan M DomchekCecilia M DorflingJacqueline EasonDouglas F EastonRos EelesChristoph EngelD Gareth EvansLaurence FaivreLidia FeliubadalóLenka ForetovaEitan FriedmanDebra FrostPatricia A GanzJudy GarberVanesa Garcia-BarberanAndrea GehrigGord GlendonAndrew K GodwinEncarna B Gómez GarciaUte HamannJan HaukeJohn L HopperPeter J HulickEvgeny N ImyanitovClaudine IsaacsLouise IzattAnna JakubowskaRamunas JanaviciusEsther M JohnBeth Y KarlanCarolien M KetsYael LaitmanConxi LázaroDominique LerouxJenny LesterFabienne LesueurJennifer T LoudJan LubińskiAlicja ŁukomskaLesley McGuffogNoura MebiroukHanne E J Meijers-HeijboerAlfons MeindlAustin MillerMarco MontagnaThea M MooijEmmanuelle Mouret-FourmeKatherine L NathansonBita NehoraySusan L NeuhausenHeli NevanlinnaFinn C NielsenKenneth OffitEdith OlahKai-Ren OngJan C OosterwijkLaura OttiniMichael T ParsonsPaolo PeterlongoGeorg PfeilerNisha PradhanPaolo RadiceSusan J RamusJohanna RantalaGad RennertMark RobsonGustavo C RodriguezRitu SalaniMaren T ScheunerRita K SchmutzlerPayal D ShahLucy E SideJacques SimardChristian F SingerDoris SteinemannDominique Stoppa-LyonnetYen Yen TanManuel R TeixeiraMary Beth TerryMads ThomassenMarc TischkowitzSilvia TognazzoAmanda Ewart TolandNadine TungChristi J van AsperenKlaartje van EngelenElizabeth J van RensburgLaurence Venat-BouvetJeroen VierstraeteGabriel WagnerLisa WalkerJeffrey N WeitzelDrakoulis Yannoukakosnull nullnull nullnull nullnull nullAntonis C AntoniouDavid E GoldgarOlufunmilayo I OlopadeGeorgia Chenevix-TrenchTimothy R RebbeckDezheng Huonull nullPublished in: British journal of cancer (2019)
Our observation of a positive association between BMI and ovarian cancer risk in premenopausal BRCA1/2 mutation carriers is consistent with findings in the general population.