Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution.
Sarah BelderbosManuel A Gonzalez GómezFrederik CleerenJens WoutersYolanda Piñeiro-RedondoChristophe M DerooseAn CoosemansWilly GsellGuy BormansJose RivasUwe HimmelreichPublished in: EJNMMI research (2020)
We present the application of novel 18F-labeled Fe3O4@Al(OH)3 NPs as safe cell tracking agents for simultaneous PET/MRI. Combining both modalities allows fast and easy NP and mMSC localization and quantification using PET at early time points, while MRI provides high-resolution, anatomic background information and long-term NP follow-up, hereby overcoming limitations of the individual imaging modalities.