Remote ischemic preconditioning inhibits platelet αIIb β3 activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial.
Jerrett K LauGabrielle J PenningsCaroline J ReddelHeather CampbellHai Po H LiangMathew TrainiElizabeth E GardinerAndy S YongVivien M ChenLeonard KritharidesPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Remote ischemic preconditioning inhibits conformational activation of platelet αIIb β3 in response to exposure to thrombin and collagen in patients with coronary artery disease receiving dual antiplatelet therapy. These findings indicate agonist-specific inhibition of platelet activation by RIPC in coronary artery disease that is not obviated by the prior use of P2Y12 inhibitors.
Keyphrases
- antiplatelet therapy
- percutaneous coronary intervention
- coronary artery disease
- acute coronary syndrome
- ischemia reperfusion injury
- coronary artery bypass grafting
- cerebral ischemia
- cardiovascular events
- molecular dynamics simulations
- molecular dynamics
- brain injury
- type diabetes
- blood brain barrier
- cardiovascular disease
- atrial fibrillation
- heart failure
- aortic stenosis
- wound healing