Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila.

Hillary K GravesPingping WangMatthew LagardeZhihong ChenJessica K Tyler

Published in: Epigenetics & chromatin (2016)

Our data suggest that chromatin structural perturbations caused by acetylation of K56, K115, or K122 and phosphorylation of T80 or T118 are important for key developmental processes.

Keyphrases

electronic health record
gene expression
dna damage
transcription factor
genome wide
big data
protein kinase
dna methylation
machine learning
data analysis
oxidative stress