Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling.

Farhad DastmalchiAida KarachiChanglin YangHassan AzariElias Joseph SayourAnjelika DechkovskaiaAlexander Loren VlasakMegan Ellen SaiaRolando Eladio LovatonDuane Anthony MitchellMaryam Rahman

Published in: Journal for immunotherapy of cancer (2019)

Sarcosine increases the migration of murine and human DCs via the CXC chemokine pathway. This platform can be utilized to improve existing DC vaccine strategies.

Keyphrases

dendritic cells
endothelial cells
regulatory t cells
immune response
induced pluripotent stem cells
high throughput