Monopronucleated (1PN) and tripronuclear (3PN) zygotes formation during assisted reproduction in POSEIDON group 4 patients: Emphasizing on polar bodies.
Ni-Chin TsaiYu-Ting SuYu-Ju LinHsin-Ju ChiangFu-Jen HuangFu-Tsai KungHsuan-Wei HuangKuo-Chung LanPublished in: The journal of obstetrics and gynaecology research (2021)
In POSEIDON group 4, most of the monopronucleated zygotes were 1PN2PB. Digyny (3PN1PB), due to failure to extrude the second PB, was the major cause of triploidy in which ICSI could not circumvent. The distribution of abnormally fertilized zygotes was similar in IVF and ICSI. To investigate the mechanisms of abnormal fertilization and assess whether ICSI is necessary, analysis of PB will provide important clues.