Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection.

Bjoern AmbrosiusKalliopi PitarokoiliLisa SchreweXiomara PedreiturriaJeremias MotteRalf Gold

Published in: Journal of neuroinflammation (2017)

Taken together, orally administered low-dose fingolimod showed an impressive immunomodulatory effect in the rat model of experimental autoimmune neuritis. Our current observations introduce fingolimod as an attractive treatment option for neuritis patients.

Keyphrases

multiple sclerosis
low dose
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
stem cells
high dose
drug induced
cell therapy
bone marrow
combination therapy
optical coherence tomography